Nagaraju, SakkaniSakkaniNagarajuSatyanarayana, NeeliNeeliSatyanarayanaPaplal, BanothBanothPaplalVasu, Anuji K.Anuji K.VasuKanvah, SriramSriramKanvahKashinath, DhurkeDhurkeKashinath2025-08-302025-08-302015-09-2110.1039/c5ra14039k2-s2.0-84942918496https://d8.irins.org/handle/IITG2025/21414Various 3-substituted-3-hydroxy isoxazole-oxindole hybrids were synthesized via the vinylogous Henry reaction of 3,5-dimethyl-4-nitroisoxazole and isatin using water as a reaction medium under catalyst free conditions at 50 °C. Systematic studies were carried out to understand the role of the water on the reaction by using D<inf>2</inf>O, brine, ethylene glycol and PEG-400 as a reaction medium along with organic solvents. Among all of these, water (0.170 mol concentration) was found be more efficient giving desired products in 82-99% yields in 45-120 min. Further the quaternary centre (3° alcohol) generated was used for the creation of a double bond which was again used for a 1,6-Michael reaction to produce highly functionalized isoxazole-oxindole derivatives.falseArticle2046206981768-8177321 September 201529arJournal26WOS:000362437900001