Nonsilyl Bicyclic Secondary Amine Catalysts for the Asymmetric Transfer Hydrogenation of α,β-Unsaturated Aldehydes

Kumar, RohtashRohtashKumarMaurya, VidyasagarVidyasagarMauryaAvinash, AvinashAvinashAvinashAppayee, ChandrakumarChandrakumarAppayee2025-08-312025-08-312024-06-2110.1021/acs.joc.4c005232-s2.0-85195325590https://d8.irins.org/handle/IITG2025/28867The first chiral synthesis of nonsilyl bicyclic secondary amine organocatalysts and their application to the asymmetric transfer hydrogenation of α,β-unsaturated aldehydes are disclosed. A lower catalytic loading (5 mol %) is demonstrated for the reduction of a wide range of α,β-unsaturated aldehydes (up to 97% yield and up to 99% ee). The application of this scalable methodology is showcased for the asymmetric synthesis of bioactive molecules such as phenoxanol, citronellol, ramelteon, and terikalant.falseNonsilyl Bicyclic Secondary Amine Catalysts for the Asymmetric Transfer Hydrogenation of α,β-Unsaturated AldehydesArticle152069048586-860021 June 20243arJournal4WOS:001242750600001