Chakraborty, ArnabArnabChakrabortySingh, KhushwantKhushwantSinghVaswani, PayalPayalVaswaniGangrade, AnkitAnkitGangradeBhatia, DhirajDhirajBhatiaDas, NeeladriNeeladriDas2025-08-312025-08-312023-08-0110.1002/aoc.71722-s2.0-85162676432https://d8.irins.org/handle/IITG2025/26696Syntheses of five (1–5) cationic organometallic complexes bearing two platinum (II) centers are being reported. Compounds 1 and 2 have a flexible molecular backbone and are isomeric. Compounds 3, 4, and 5 are structural isomers with a rigid structural framework and containing pyrimidine/pyrazine in the center and two pendant arms bearing the alkynyl–ditopic platinum units. Compounds 1–5 were systematically characterized using FT-IR, NMR [¹H, ³¹P{¹H}, and ¹³C{¹H}], and HRMS. The antiproliferative activity of these compounds was examined against HeLa cancer cell line, and results were compared with that of cisplatin. “Live/dead” cell death assay was performed to ratify the superior antiproliferative activities of some of these organometallic complexes with respect to cisplatin.falseantiproliferative | flexible and rigid | HeLa | ionic organoplatinum | MTT | pyrazine | pyrimidineArticle10990739August 20231e7172arJournal2WOS:001011550200001