Somanatha, T. M.T. M.SomanathaKrishnaswamy, G.G.KrishnaswamyNayana, R.R.NayanaNayana, J.J.NayanaBhavana, R.R.BhavanaShivaraj, G.G.ShivarajSreenivasa, S.S.SreenivasaShet Prakash, M.M.Shet Prakash2025-08-312025-08-312023-09-0110.25303/2709rjce01072-s2.0-85174609044https://d8.irins.org/handle/IITG2025/26654In the present investigation, Schiff bases (SBs) bearing 1, 2, 3-triazole and furan motif were synthesized through condensation reaction via conventional approach (Route-A) and solvent free approach (Route-B). It has been found that route-B is efficient since it is eco friendly with short reaction time and satisfactory yield than route-A. The structure and formation of targeted Schiff bases (SBs) were confirmed by different spectroscopic techniques (¹H NMR, ¹³C NMR and Mass). Finally, in vitro antimicrobial screening result revealed that the synthesised SBs derivatives may act as moderate antimicrobial agents.false1, 2, 3-Triazole | aromatic azides | biological profile | Schiff base | substituted furaldehydeArticle227845271-7September 20230arJournal0