Ghana, PriyabrataPriyabrataGhanaMorris, Louis J.Louis J.MorrisOkuda, JunJunOkuda2025-08-312025-08-312025-05-2910.1039/d4dt03357d2-s2.0-105007994035https://d8.irins.org/handle/IITG2025/2812640476815Currently, there is considerable interest in introducing molecularly defined main group metal compounds as precursors and model complexes of homogeneous catalysts for various bond cleavage and forming transformations. With a focus on the NNNN macrocyclic ligand Me<inf>4</inf>TACD (N,N′,N′′,N′′′-tetramethyl-1,4,7,10-tetraazacyclododecane), this review summarizes the versatility of the ligand Me<inf>4</inf>TACD for the stabilization of reactive main group s- and p-block (group 1, 2, 12-14) metals. Metal hydrides, hydrocarbyls and silyls are often monomeric and catalyze alkene hydrofunctionalisations. In contrast to the rich coordination chemistry of d- and f-block transition metals using a plethora of ligands, main group metals still leave room for new structures and reactivities, aligning with the current efforts to develop a systematic understanding in s- and p-block metal-ligand combinations.trueReviewhttps://pubs.rsc.org/en/content/articlepdf/2025/dt/d4dt03357d1477923410504-1054029 May 20250reJournal0