Maurya, VidyasagarVidyasagarMauryaAppayee, ChandrakumarChandrakumarAppayee2025-08-302025-08-302018-07-0610.1021/acs.orglett.8b016672-s2.0-85049638744https://d8.irins.org/handle/IITG2025/2281229916715The first catalytic approach for the asymmetric synthesis of 3,4-disubstituted cyclohexadiene carbaldehydes through an inverse-electron-demand Diels-Alder reaction is described. A variety of arylacetaldehydes and α,β,γ,δ-unsaturated aldehydes are tested under the mild reaction conditions catalyzed by l-proline to obtain the trans diastereomeric products with good yields and high enantioselectivities. The scope of this methodology is further extended to the asymmetric synthesis 3,4-disubstituted cyclohexane carbaldehydes and their derivatives. The practicality of this method is demonstrated by the gram-scale synthesis. This methodology is successfully applied for the formal total synthesis of cyclobakuchiol A, an antipyretic and anti-inflammatory agent, and cyclobakuchiol C.falseArticle152370524111-41156 July 20186arJournal5WOS:000438469500090