Nagaraju, SakkaniSakkaniNagarajuSatyanarayana, NeeliNeeliSatyanarayanaPaplal, BanothBanothPaplalVasu, Anuji K.Anuji K.VasuKanvah, SriramSriramKanvahSridhar, BalasubramanianBalasubramanianSridharSripadi, PrabhakarPrabhakarSripadiKashinath, DhurkeDhurkeKashinath2025-08-302025-08-302015-10-2910.1039/c5ra16721c2-s2.0-84946551017https://d8.irins.org/handle/IITG2025/21399One-pot synthesis of highly functionalized tetrahydrothiophene (thiolane) derivatives conjugated with biologically useful isooxazole are reported via the Knoevenagel condensation followed by domino sulfa-1,6-Michael/intramolecular vinylogous Henry reactions of aldehydes, 1,4-dithiane-2,5-diol and 3,5-dimethyl-4-nitroisoxazole. From the base and solvent screening, it was found that piperidine (30 mol%) and ethanol are the most suitable conditions giving the desired products with >95% yields in 2-2.5 h overall reaction time.falseArticle2046206994474-9447829 October 201520arJournal18WOS:000364073700096