Rai, Sachchida NandSachchida NandRaiSingh, PayalPayalSinghVarshney, RituRituVarshneyChaturvedi, Vivek K.Vivek K.ChaturvediVamanu, EmanuelEmanuelVamanuSingh, M. P.M. P.SinghSingh, Brijesh KumarBrijesh KumarSingh2025-08-312025-08-312021-09-0110.4103/1673-5374.3060662-s2.0-85100340257https://d8.irins.org/handle/IITG2025/25324Parkinson's disease (PD) is one of the most debilitating brain diseases. Despite the availability of symptomatic treatments, response towards the health of PD patients remains scarce. To fulfil the medical needs of the PD patients, an efficacious and etiological treatment is required. In this review, we have compiled the information covering limitations of current therapeutic options in PD, novel drug targets for PD, and finally, the role of some critical beneficial natural products to control the progression of PD.truedopamine | epigenetics | gene therapies | glutamate receptor | levodopa | molecular chaperones | monoamine oxidase B | mucuna alpha-synuclein | Parkinson's disease | striatum | substantia nigraReviewhttps://doi.org/10.4103/1673-5374.306066187679581730-1739September 202191reJournal86