Arora, AnkitaAnkitaAroraMajhi, SasmitaSasmitaMajhiMishra, AbhijitAbhijitMishra2025-08-312025-08-312021-01-0110.1016/j.matpr.2021.09.4092-s2.0-85123413213https://d8.irins.org/handle/IITG2025/26378Antimicrobial peptides (AMPs) are considered as promising candidates to combat emergence of multidrug-resistant bacteria. However, they usually have complex structures and are expensive to produce. Herein we design a short, potent, pore-forming antibacterial peptide utilizing the two basic features of AMPs: cationicity and hydrophobicity. The designed peptide, KLR is evaluated for its antibacterial potency. The results reveal that KLR is a potent AMP that inhibits growth of E. coli and S. aureus with minimal inhibitory concentration (MIC) similar to that of full-length AMPs and is non-toxic towards mammalian cells. We also show that KLR kills bacteria by forming membrane pores making it less susceptible to development of bacterial resistance.falseAntibacterial assay | Antimicrobial resistance | Cytotoxicity | Hydrophobicity | Peptide-lipid interaction | Pore forming peptideConference Paper221478532392-239620214cpConference Proceeding3