Chilka, P.P.ChilkaPatlolla, P. R.P. R.PatlollaDatta, B.B.Datta2025-08-302025-08-302016-01-0110.1039/c6ra05474a2-s2.0-84987779153https://d8.irins.org/handle/IITG2025/21984A novel dimeric carbocyanine dye is found to recognise G-quadruplex structures selectively compared to mixed sequence or double-stranded DNA molecules. The dye exhibits a preference for G3-bearing parallel quadruplexes and results in a nearly 1400-fold enhancement compared to the absence of DNA and a nearly 30-fold fluorescence enhancement compared to duplex and single stranded DNA molecules. Study of the dye binding with various quadruplex-forming sequences points towards an end-stacking mechanism of interaction. The number of G-quartets and spacer sequences along with the identity of monovalent ions strongly influence the interaction of quadruplexes with the dye.falseArticle2046206987400-8740420169arJournal9