Sathisaran, IndumathiIndumathiSathisaranDalvi, Sameer VishvanathSameer VishvanathDalvi2025-08-312025-08-312021-01-0110.1208/s12249-020-01888-62-s2.0-85098747967https://d8.irins.org/handle/IITG2025/2557333404968In this work, carbamazepine (CBZ), an anticonvulsant drug was cocrystallized with several structurally complement coformers (coformers with amide, acid and hydrazide functional groups) to enhance its dissolution. CBZ formed a cocrystal phase with acetamide (ACE) when mixtures of CBZ and ACE (containing CBZ mole fractions, X<inf>CBZ</inf> of 0.25, 0.33, 0.5, and 0.67) were subjected to solid-state grinding (SSG), evaporative crystallization (EC), slurry conversion (SC), and slow cooling crystallization (SLC). Upon heating, the CBZ-ACE cocrystal phase formed from CBZ-ACE mixtures containing X<inf>CBZ</inf> of 0.25, 0.33 and 0.67 underwent solid-state phase transition to CBZ form I and CBZ cocrytsal phase obtained from the CBZ-ACE mixture containing X<inf>CBZ</inf> of 0.5 converted to CBZ form III. Interestingly, slow cooling cocrystallization experiments resulted in crystallization of a cocrystal as well as the CBZ dihydrate forms. The powder dissolution studies demonstrated that among the different CBZ-ACE-SSG cocrystal phases, CBZ-ACE-SSG-X<inf>CBZ</inf>-0.33 cocrystal exhibited 7.47 times improved dissolution whereas the CBZ eutectic phase with nicotinic acid hydrazide (NAH) exhibited 4.93 times increased dissolution when compared to raw CBZ.falseacetamide | acid | carbamazepine | cocrystal | coformers | dissolution | eutectic | hydrazideArticle15309932January 20211629arJournal12