Kutwal, Mahesh S.Mahesh S.KutwalDev, SachinSachinDevAppayee, ChandrakumarChandrakumarAppayee2025-08-312025-08-312019-04-1910.1021/acs.orglett.8b041102-s2.0-85064689115https://d8.irins.org/handle/IITG2025/2330630938529The first vinylogous aldol condensation of α,β-unsaturated aldehydes using aqueous formaldehyde is developed under mild reaction conditions to form the γ-methylenated products with excellent regioselectivity. Using this methodology, a short synthesis of α-triticene, an antifungal compound, is achieved in two steps. The practicality of this methodology is demonstrated by the gram-scale synthesis. Formation of the unusual double γ-functionalized products from crotonaldehyde and a direct asymmetric vinylogous aldol product from phenylglyoxal is also described.falseArticle152370522509-251319 April 20197arJournal10WOS:000465644300004