Maurya, VidyasagarVidyasagarMauryaAppayee, ChandrakumarChandrakumarAppayee2025-08-312025-08-312020-01-1710.1021/acs.joc.9b029622-s2.0-85077700429https://d8.irins.org/handle/IITG2025/2424231833372The first total synthesis of potent cannabinoid, 9β-11-hydroxyhexahydrocannabinol, is achieved through a proline-catalyzed inverse-electron-demand Diels-Alder reaction. Using this asymmetric catalysis, the cyclohexane ring is constructed with two chiral centers as a single diastereomer with 97% ee. The creation of the third chiral center and benzopyran ring is demonstrated with the elegant synthetic strategies. This mild and efficient synthetic methodology provides a new route for the asymmetric synthesis of the other potent hexahydrocannabinols.falseArticle152069041291-129717 January 20208arJournal7WOS:000508468900094