Kanvah, SriramSriramKanvahSchuster, Gary B.Gary B.Schuster2025-08-302025-08-302011-03-0110.1139/V10-1452-s2.0-79953248530https://d8.irins.org/handle/IITG2025/21076A series of DNA oligomers were prepared that contain guanidinium linkages (positively charged) positioned selectively in place of and among the normal negatively charged phosphodiester backbone groups of duplex DNA. One-electron oxidation of these DNA oligomers by UV irradiation of a covalently linked anthraquinone group generates a radical cation (electron "hole") that migrates by hopping through the DNA and is trapped at reactive sites, GG steps, to form mutated bases that are detected by strand cleavage after subsequent piperidine treatment of the irradiated DNA. Analysis of the strand cleavage pattern reveals that guanidinium substitution in these oligomers does not measurably affect the charge migration rate but it does inhibit reaction at nearby guanines.falseAnthraquinone photosensitizer | Charge transport | DNA oxidation | Guanidinium backboneArticle326-330March 20111arJournal1WOS:000288565100010