Probiotics for Management of Gastrointestinal Cancers

Probiotics has been used for management of genetically predisposed health disorders associated with gastrointestinal (GI) tract. Administration of specific probiotics in defined doses causes revitalization of healthy gut microflora that can positively modulate immune response within GI tract and hence, aid in the management of inflammation of intestinal mucosa. Thus, it has potential of becoming a durable therapeutic approach to resolve metabolism related disorders including GI cancers. Probiotic-induced competition can exclude and replace pathogenic microorganisms from GI cancer-induced niche in gut. Notably, oral administration of probiotics is a key driving factor for the ease of management of post-operative complications of GI tract cancers. Here, we attempt to summarize the diversified knowledge of probiotics to utilize as therapeutic tool in prevention, progression and treatment of GI tract cancer, current challenges of probiotics in regulating GI cancer progression, and future perspectives.