New 1, 2, 3-triazole-Furan Scaffold Schiff bases: Design, Synthesis, Characterization and biological studies
Source
Research Journal of Chemistry and Environment
ISSN
09720626
Date Issued
2023-09-01
Author(s)
Somanatha, T. M.
Krishnaswamy, G.
Nayana, R.
Nayana, J.
Bhavana, R.
Shivaraj, G.
Sreenivasa, S.
Shet Prakash, M.
Abstract
In the present investigation, Schiff bases (SBs) bearing 1, 2, 3-triazole and furan motif were synthesized through condensation reaction via conventional approach (Route-A) and solvent free approach (Route-B). It has been found that route-B is efficient since it is eco friendly with short reaction time and satisfactory yield than route-A. The structure and formation of targeted Schiff bases (SBs) were confirmed by different spectroscopic techniques (<sup>1</sup>H NMR, <sup>13</sup>C NMR and Mass). Finally, in vitro antimicrobial screening result revealed that the synthesised SBs derivatives may act as moderate antimicrobial agents.
Subjects
1, 2, 3-Triazole | aromatic azides | biological profile | Schiff base | substituted furaldehyde